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Nanoscale Heterogeneities Drive Enhanced Binding and Anomalous Diffusion of Nanoparticles in Model Biomembranes

Interaction of functional nanoparticles with cells and model biomembranes has been widely studied to evaluate the effectiveness of the particles as potential drug delivery vehicles and bioimaging labels as well as in understanding nanoparticle cytotoxicity effects. Charged nanoparticles, in particular, with tunable surface charge have been found to be effective in targeting cellular membranes as well as the subcellular matrix. However, a microscopic understanding of the underlying physical principles that govern nanoparticle binding, uptake, or diffusion on cells is lacking. Here, we report the first experimental studies of nanoparticle diffusion on model biomembranes and correlate this to the existence of nanoscale dynamics and structural heterogeneities using super-resolution stimulated emission depletion (STED) microscopy. Using confocal and STED microscopy coupled with fluorescence correlation spectroscopy (FCS), we provide novel insight on why these nanoparticles show enhanced binding on two-componen...

Authors:   Roobala Chelladurai; Koushik Debnath; Nikhil R. Jana; Jaydeep Kumar Basu
Journal:   Langmuir
Year:   2018
DOI:   10.1021/acs.langmuir.7b04003
Publication date:   19-Jan-2018
Facts, background information, dossiers
  • Matrix
  • fluorescence correl…
  • drug delivery
  • cytotoxicity
  • cells
  • bioimaging
More about American Chemical Society Publications
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