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Design of a Single-Layer Microchannel for Continuous Sheathless Single-Stream Particle Inertial Focusing

High-throughput, high-precision single-stream focusing of microparticles has a potentially wide range of applications in biochemical analysis and clinical diagnosis. In this work, we develop a sheathless three-dimensional (3D) particle-focusing method in a single-layer microchannel. This novel microchannel consists of periodic high-aspect-ratio curved channels and straight channels. The proposed method takes advantage of both the curved channels, which induce Dean flow to promote particle migration, and straight channels, which suppress the remaining stirring effects of Dean flow to stabilize the achieved particle focusing. The 3D particle focusing is demonstrated experimentally, and the mechanism is analyzed theoretically. The effects of flow rate, particle size, and cycle number on the focusing performance were also investigated. The experimental results demonstrate that polystyrene particles with diameters of 5–20 μm can be focused into a 3D single file within seven channel cycles, with the focusing ac...

Authors:   Yan Zhang; Jun Zhang; Fei Tang; Weihua Li; Xiaohao Wang
Journal:   Analytical Chemistry
Year:   2018
DOI:   10.1021/acs.analchem.7b03756
Publication date:   17-Jan-2018
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