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A Novel Approach to Increase the Stability of Liposomal Containers via In Prep Coating by Poly[N‐(2‐Hydroxypropyl)Methacrylamide] with Covalently Attached Cholesterol Groups

Abstract

Highly stable liposomes are developed by coating phosphatidylcholine liposomes with amphiphilic N‐(2‐hydroxypropyl)methacrylamide copolymer. Two approaches in the preparation of coated liposomes are employed: the copolymer is added during (“in prep”) or after (“ex post”) the liposome formation. The influence of polymer concentration and coating method is evaluated using the cryogenic transmission electron microscopy, dynamic light scattering, and small‐angle X‐ray scattering techniques. The in prep modification significantly increases, up to four weeks, the stability of liposomes against aggregation and makes the liposomal membrane nonpermeable toward an inorganic salt. Such enhanced longevity is attributed to the different structure of in prep coated liposomal membranes.

“In prep” and “ex post” coated liposomes shows higher stability compared with uncoated liposomes in both longevity and preservation of the loaded compound. In prep coated liposomes manifest the highest stability over one month, which is also fair for the physiological media. The highest stability of in prep coated liposomes is attributed to the unique structure of their membrane, which is proved by small‐angle X‐ray scattering experiments.

Authors:   Olga V. Zaborova, Sergey K. Filippov, Petr Chytil, Lubomir Kováčik, Karel Ulbrich, Alexander A. Yaroslavov, Tomaš Etrych
Journal:   Macromolecular Chemistry and Physics
Year:   2018
Pages:   n/a
DOI:   10.1002/macp.201700508
Publication date:   19-Jan-2018
Facts, background information, dossiers
  • liposomes
  • stability
  • scattering
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