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Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress [Psychological and Cognitive Sciences]

The discovery that neurotransmitter identity is regulated by activity in the adult mammalian brain during a stress response raises questions about the extent and function of this plasticity. Specific synapses are associated with the release of a particular neurotransmitter or transmitters on the basis of evidence obtained under a single set of conditions. Transmitter switching endows the connectome with greater plasticity: Activity-dependent revision of signaling provides another dimension of flexibility to regulate normal behavior. Changes in transmitter identity are also positioned to contribute to diseases of the nervous system. Neurotransmitter imbalance has long been implicated in common neurological and psychiatric disorders, provoking interest in transmitter switching as a therapeutic tool for patients.

Authors:   Da Meng; Hui-quan Li; Karl Deisseroth; Stefan Leutgeb; Nicholas C. Spitzer
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   20
Year:   2018
Pages:   5064
DOI:   10.1073/pnas.1801598115
Publication date:   15-May-2018
Facts, background information, dossiers
  • synapses
  • stress
  • Single
  • psychiatric disorders
  • diseases
More about Proceedings of the National Academy of Sciences
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