My watch list
my.chemeurope.com  
Login  

Preparation and application of a carbon paste electrode modified with multi-walled carbon nanotubes and boron-embedded molecularly imprinted composite membranes

Publication date:

June 2018


Source:Bioelectrochemistry, Volume 121

Author(s): Hongjuan Wang, Duo Qian, Xilin Xiao, Chunyan Deng, Lifu Liao, Jian Deng, Ying-Wu Lin

An innovative electrochemical sensor was fabricated for the sensitive and selective determination of tinidazole (TNZ), based on a carbon paste electrode (CPE) modified with multi-walled carbon nanotubes (MWCNTs) and boron-embedded molecularly imprinted composite membranes (B-MICMs). Density functional theory (DFT) calculations were carried out to investigate the utility of template-monomer interactions to screen appropriate monomers for the rational design of B-MICMs. The distinct synergic effect of MWCNTs and B-MICMs was evidenced by the positive shift of the reduction peak potential of TNZ at B-MICMs/MWCNTs modified CPE (B-MICMs/MWCNTs/CPE) by about 200 mV, and the 12-fold amplification of the peak current, compared with a bare carbon paste electrode (CPE). Moreover, the coordinate interactions between trisubstituted boron atoms embedded in B-MICMs matrix and nitrogen atoms of TNZ endow the sensor with advanced affinity and specific directionality. Thereafter, a highly sensitive electrochemical analytical method for TNZ was established by different pulse voltammetry (DPV) at B-MICMs/MWCNTs/CPE with a lower detection limit (1.25 × 10−12 mol L−1) (S/N = 3). The practical application of the sensor was demonstrated by determining TNZ in pharmaceutical and biological samples with good precision (RSD 1.36% to 3.85%) and acceptable recoveries (82.40%–104.0%).
Graphical abstract




Authors:   Author(s): Hongjuan Wang, Duo Qian, Xilin Xiao, Chunyan Deng, Lifu Liao, Jian Deng, Ying-Wu Lin
Journal:   Bioelectrochemistry
Volume:   121
Year:   2018
Pages:   115
DOI:   10.1016/j.bioelechem.2018.01.006
Publication date:   15-Apr-2018
Facts, background information, dossiers
  • biological samples
  • amplification
More about Elsevier
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE