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Benzopyrroloxazines containing a bridgehead nitrogen atom as promising scaffolds for the achievement of biologically active agents

Publication date:

10 May 2018


Source:European Journal of Medicinal Chemistry, Volume 151

Author(s): Fedora Grande, Maria A. Occhiuzzi, Giuseppina Ioele, Gaetano Ragno, Antonio Garofalo

The present review lists the papers and patents dealing with the class of polycondensed heterocycles called benzopyrroloxazines published in the last decades. The survey is limited to substances characterized by the presence of a bridgehead N atom, which means that the present N atom serves to connect different rings within the same molecule. In the case of benzopyrroloxazines, the bridgehead N atom belongs at the same time to the pyrrole and oxazine rings. All other compounds not possessing this feature were kept out accordingly. Relevant synthetic methods to such compounds have been outlined. Many different biological properties have been attributed to several functionalized derivatives of these heterocycles and cited within the review.
Graphical abstract




Authors:   Author(s): Fedora Grande, Maria A. Occhiuzzi, Giuseppina Ioele, Gaetano Ragno, Antonio Garofalo
Journal:   European Journal of Medicinal Chemistry
Volume:   151
Year:   2018
Pages:   121
DOI:   10.1016/j.ejmech.2018.03.061
Publication date:   15-Apr-2018
Facts, background information, dossiers
  • medicinal chemistry
  • active agents
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