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Clarifying the role of cryo- and lyo-protectants in the biopreservation of proteins

Biopharmaceuticals are frequently stored in the frozen state to avoid rapid degradation. Moreover, therapeutic proteins are frequently made into a dried form to provide long-term storage. However, both freezing and drying stresses can result in protein unfolding and aggregation. Thus, a proper formulation, c

Authors:   Andrea Arsiccio; Roberto Pisano
Journal:   Physical Chemistry Chemical Physics
Volume:   20
edition:   12
Pages:   8267
DOI:   10.1039/C7CP08029H
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