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Radiosynthesis of the anticancer nucleoside analogue Trifluridine using an automated 18F-trifluoromethylation procedure

Trifluoromethyl groups are widespread in medicinal chemistry, yet there are limited 18F-radiochemistry techniques available for the production of the complementary PET agents. Herein, we report the first radiosynthesis of the anticancer nucleoside analogue trifluridine, using a fully automated, clinically-ap

Authors:   Alice King; Andreas Doepner; David Turton; Daniela M. Ciobota; Chiara Da Pieve; Anne-Christine Wong Te Fong; Gabriela Kramer-Marek; Yuen-Li Chung; Graham Smith
Journal:   Organic & Biomolecular Chemistry
Volume:   16
edition:   16
Pages:   2986
DOI:   10.1039/C8OB00432C
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  • medicinal chemistry
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