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Molbank, Vol. 2018, Article M989: (Z)-4-[2-(3,4-Difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one

Molbank, Vol. 2018, Article M989: (Z)-4-[2-(3,4-Difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one

Molbank doi: 10.3390/M989

Authors: Billava Mohan Balladka Sarojini Badiadka Narayana Enumadishetty Sindhu Priya

The title compound (Z)-4-[2-(3,4-difluorophenyl)hydrazono]-3-methyl-1H-pyrazol-5(4H)-one 4 was synthesized by the reaction of ethyl 2-[2-(3,4-difluorophenyl)hydrazono]-3-oxobutanoate 3 with hydrazine hydrate. The diazotization of 3,4-difluoroaniline, followed by the treatment with ethyl acetoacetate, afforded intermediate 3. The synthesized compound 4 was characterized by FTIR, 1H-NMR, 13C-NMR and LCMS, and it showed synergistic anti-inflammatory, antiproliferative and antibacterial activities.

Authors:   Mohan, Billava Jayappa; Sarojini, Balladka Kunhanna; Narayana, Badiadka ; Sindhu Priya, Enumadishetty Srinivasulu
Journal:   Molbank
Volume:   2018
edition:   2
Year:   2018
Pages:   M989
DOI:   10.3390/M989
Publication date:   31-Mar-2018
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