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Materials, Vol. 11, Pages 258: Hydroxyapatite Microspheres as an Additive to Enhance Radiopacity, Biocompatibility, and Osteoconductivity of Poly(methyl methacrylate) Bone Cement

Materials, Vol. 11, Pages 258: Hydroxyapatite Microspheres as an Additive to Enhance Radiopacity, Biocompatibility, and Osteoconductivity of Poly(methyl methacrylate) Bone Cement

Materials doi: 10.3390/ma11020258

Authors: In-Gu Kang Cheon-Il Park Hyun Lee Hyoun-Ee Kim Sung-Mi Lee

This study demonstrates the utility of hydroxyapatite (HA) microspheres as an additive to enhance the radiopaque properties, biocompatibility, and osteoconductivity of poly(methyl methacrylate) (PMMA)-based bone cements. HA microspheres were synthesized using spray drying. They had well-defined spherical shapes, thus allowing for the production of PMMA/HA composites with a very high HA content (20 vol % and 40 vol %). The uniform distribution of these HA microspheres in the PMMA matrix resulted in a remarkable increase in compressive modulus (p < 0.05), while preserving a reasonably high compressive strength. The PMMA/HA bone cements showed much higher radiopacity than PMMA containing BaSO4 as the additive. This was attributed to the high HA content up to 40 vol %. In addition, the biocompatibility and osteoconductivity of PMMA/HA bone cements were significantly enhanced compared to those of PMMA bone cements containing BaSO4, which were assessed using in vitro tests and in vivo animal experiments.

Authors:   Kang, In-Gu ; Park, Cheon-Il ; Lee, Hyun ; Kim, Hyoun-Ee ; Lee, Sung-Mi
Journal:   Materials
Volume:   11
edition:   2
Year:   2018
Pages:   258
DOI:   10.3390/ma11020258
Publication date:   07-Feb-2018
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