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Molecules, Vol. 23, Pages 661: Influence of Storage Temperature on Radiochemical Purity of 99mTc-Radiopharmaceuticals

Molecules, Vol. 23, Pages 661: Influence of Storage Temperature on Radiochemical Purity of 99mTc-Radiopharmaceuticals

Molecules doi: 10.3390/molecules23030661

Authors: Licia Uccelli Alessandra Boschi Petra Martini Corrado Cittanti Stefania Bertelli Doretta Bortolotti Elena Govoni Luca Lodi Simona Romani Samanta Zaccaria Elisa Zappaterra Donatella Farina Carlotta Rizzo Melchiore Giganti Mirco Bartolomei

The influence of effective room temperature on the radiochemical purity of 99mTc-radiopharmaceuticals was reported. This study was born from the observation that in the isolators used for the preparation of the 99mTc-radiopharmaceuticals the temperatures can be higher than those reported in the commercial illustrative leaflets of the kits. This is due, in particular, to the small size of the work area, the presence of instruments for heating, the continuous activation of air filtration, in addition to the fact that the environment of the isolator used for the 99mTc-radiopharmaceuticals preparation and storage is completely isolated and not conditioned. A total of 244 99mTc-radiopharmaceutical preparations (seven different types) have been tested and the radiochemical purity was checked at the end of preparation and until the expiry time. Moreover, we found that the mean temperature into the isolator was significantly higher than 25 °C, the temperature, in general, required for the preparation and storage of 99mTc-radiopharmaceuticals. Results confirmed the radiochemical stability of radiopharmaceutical products. However, as required in the field of quality assurance, the impact that different conditions than those required by the manufacturer on the radiopharmaceuticals quality have to be verified before human administration.

Authors:   Uccelli, Licia ; Boschi, Alessandra ; Martini, Petra ; Cittanti, Corrado ; Bertelli, Stefania ; Bortolotti, Doretta ; Govoni, Elena ; Lodi, Luca ; Romani, Simona ; Zaccaria, Samanta ; Zappaterra, Elisa ; Farina, Donatella ; Rizzo, Carlotta ; Giganti, Melchiore ; Bartolomei, Mirco
Journal:   Molecules
Volume:   23
edition:   3
Year:   2018
Pages:   661
DOI:   10.3390/molecules23030661
Publication date:   15-Mar-2018
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  • stability
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