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Molecules, Vol. 23, Pages 1008: Nanotechnological Strategies for Protein Delivery

Molecules, Vol. 23, Pages 1008: Nanotechnological Strategies for Protein Delivery

Molecules doi: 10.3390/molecules23051008

Authors: María Rocío Villegas Alejandro Baeza María Vallet-Regí

The use of therapeutic proteins plays a fundamental role in the treatment of numerous diseases. The low physico-chemical stability of proteins in physiological conditions put their function at risk in the human body until they reach their target. Moreover, several proteins are unable to cross the cell membrane. All these facts strongly hinder their therapeutic effect. Nanomedicine has emerged as a powerful tool which can provide solutions to solve these limitations and improve the efficacy of treatments based on protein administration. This review discusses the advantages and limitations of different types of strategies employed for protein delivery, such as PEGylation, transport within liposomes or inorganic nanoparticles or their in situ encapsulation.

Authors:   Villegas, María Rocío; Baeza, Alejandro ; Vallet-Regí, María
Journal:   Molecules
Volume:   23
edition:   5
Year:   2018
Pages:   1008
DOI:   10.3390/molecules23051008
Publication date:   25-Apr-2018
Facts, background information, dossiers
  • proteins
  • molecules
  • therapeutic proteins
  • nanomedicine
  • liposomes
  • inorganic nanoparticles
  • encapsulation
  • diseases
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