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IJMS, Vol. 19, Pages 1127: In Vitro and In Vivo Osteogenic Activity of Titanium Implants Coated by Pulsed Laser Deposition with a Thin Film of Fluoridated Hydroxyapatite

IJMS, Vol. 19, Pages 1127: In Vitro and In Vivo Osteogenic Activity of Titanium Implants Coated by Pulsed Laser Deposition with a Thin Film of Fluoridated Hydroxyapatite

International Journal of Molecular Sciences doi: 10.3390/ijms19041127

Authors: Luyuan Chen Satoshi Komasa Yoshiya Hashimoto Shigeki Hontsu Joji Okazaki

To enhance biocompatibility, osteogenesis, and osseointegration, we coated titanium implants, by krypton fluoride (KrF) pulsed laser deposition, with a thin film of fluoridated hydroxyapatite (FHA). Coating was confirmed by scanning electron microscopy (SEM) and scanning probe microscopy (SPM), while physicochemical properties were evaluated by attenuated reflectance Fourier transform infrared spectroscopy (ATR-FTIR). Calcium deposition, osteocalcin production, and expression of osteoblast genes were significantly higher in rat bone marrow mesenchymal stem cells seeded on FHA-coated titanium than in cells seeded on uncoated titanium. Implantation into rat femurs also showed that the FHA-coated material had superior osteoinductive and osseointegration activity in comparison with that of traditional implants, as assessed by microcomputed tomography and histology. Thus, titanium coated with FHA holds promise as a dental implant material.

Authors:   Chen, Luyuan ; Komasa, Satoshi ; Hashimoto, Yoshiya ; Hontsu, Shigeki ; Okazaki, Joji
Journal:   International Journal of Molecular Sciences
Volume:   19
edition:   4
Year:   2018
Pages:   1127
DOI:   10.3390/ijms19041127
Publication date:   10-Apr-2018
Facts, background information, dossiers
  • scanning electron m…
  • production
  • osteogenesis
  • implants
  • hydroxyapatite
  • histology
  • genes
  • Expression
  • deposition
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