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IJMS, Vol. 19, Pages 775: PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine—An Overview

IJMS, Vol. 19, Pages 775: PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine—An Overview

International Journal of Molecular Sciences doi: 10.3390/ijms19030775

Authors: Ana Rey-Rico Magali Cucchiarini

Lineal (poloxamers or Pluronic®) or X-shaped (poloxamines or Tetronic®) amphiphilic tri-block copolymers of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled drug delivery in different regenerative medicine approaches. The ability of these copolymers to self-assemble as micelles and to undergo sol-to-gel transitions upon heating has endowed the denomination of “smart” or “intelligent” systems. The use of PEO-PPO-PEO copolymers as gene delivery systems is a powerful emerging strategy to improve the performance of classical gene transfer vectors. This review summarizes the state of art of the application of PEO-PPO-PEO copolymers in both nonviral and viral gene transfer approaches and their potential as gene delivery systems in different regenerative medicine approaches.

Authors:   Rey-Rico, Ana ; Cucchiarini, Magali
Journal:   International Journal of Molecular Sciences
Volume:   19
edition:   3
Year:   2018
Pages:   775
DOI:   10.3390/ijms19030775
Publication date:   08-Mar-2018
Facts, background information, dossiers
  • drug delivery
  • Art
  • ANA
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