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MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells [Medical Sciences]

Gliomas exhibit high proportions of glioma stem cells (GSCs), anoikis resistance, increased brain parenchyma invasion, and resistance to therapy with high recurrence. GSCs display protective autophagy, a self-mediated lysosomal degradation process that balances sources of energy at critical times of stress. Protective autophagy in GSCs promotes resistance to anoikis, programmed death resulting from growth in an anchorage-independent manner. MDA-9 is critical in maintaining protective autophagy in GSCs, thereby contributing to anoikis-resistance. MDA-9 regulates critical molecules, including BCL2 and EGFR, which control autophagy. A link between MDA-9 and protective autophagy and anoikis-resistance identifies an Achilles’ heel of glioblastoma multiforme that may be exploited to define enhanced therapies with improved prognosis and decreased recurrence. Accordingly, targeting MDA-9 may represent a viable therapeutic strategy for glioblastoma multiforme.

Authors:   Sarmistha Talukdar; Anjan K. Pradhan; Praveen Bhoopathi; Xue-Ning Shen; Laura A. August; Jolene J. Windle; Devanand Sarkar; Frank B. Furnari; Webster K. Cavenee; Swadesh K. Das; Luni Emdad; Paul B. Fisher
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   22
Year:   2018
Pages:   5768
DOI:   10.1073/pnas.1721650115
Publication date:   29-May-2018
Facts, background information, dossiers
  • autophagy
  • anoikis
  • stem cells
  • stress
  • molecules
  • glioblastoma multiforme
More about Proceedings of the National Academy of Sciences
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