My watch list  

The glycolipid GM1 reshapes asymmetric biomembranes and giant vesicles by curvature generation [Chemistry]

The multifaceted involvement of GM1 as a ligand in many cellular functions has been well recognized. We find that GM1 readily desorbs from the membrane of cell-sized model biomimetic systems (giant unilamellar vesicles). The desorption is unbalanced, creating an asymmetry between the bilayer leaflets. This results in reshaping weakly curved membranes into nanotubular invaginations stabilized by the membrane spontaneous curvature, which we quantify experimentally. Computer simulations confirm the experimental results. Uncovering the role of GM1 as a fine regulator of membrane curvature broadens our perspective on its important function in reshaping neuronal membranes and emphasizes that GM1 desorption can strongly affect the cell membrane morphology.

Authors:   Raktim Dasgupta; Markus S. Miettinen; Nico Fricke; Reinhard Lipowsky; Rumiana Dimova
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   22
Year:   2018
Pages:   5756
DOI:   10.1073/pnas.1722320115
Publication date:   29-May-2018
Facts, background information, dossiers
More about Proceedings of the National Academy of Sciences
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE