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Sensors, Vol. 18, Pages 964: Green, Hydrothermal Synthesis of Fluorescent Carbon Nanodots from Gardenia, Enabling the Detection of Metronidazole in Pharmaceuticals and Rabbit Plasma

Sensors, Vol. 18, Pages 964: Green, Hydrothermal Synthesis of Fluorescent Carbon Nanodots from Gardenia, Enabling the Detection of Metronidazole in Pharmaceuticals and Rabbit Plasma

Sensors doi: 10.3390/s18040964

Authors: Xiupei Yang Mingxian Liu Yanru Yin Fenglin Tang Hua Xu Xiangjun Liao

Strong fluorescent carbon nanodots (FCNs) were synthesized with a green approach using gardenia as a carbon source through a one-step hydrothermal method. FCNs were characterized by their UV-vis absorption spectra, photoluminescence (PL), Fourier transform infrared spectroscopy (FTIR) as well as X-ray photoelectron spectroscopy (XPS). We further explored the use of as-synthesized FCNs as an effective probe for the detection of metronidazole (MNZ), which is based on MNZ-induced fluorescence quenching of FCNs. The proposed method displayed a wide linear range from 0.8 to 225.0 µM with a correlation coefficient of 0.9992 and a limit of detection as low as 279 nM. It was successfully applied to the determination of MNZ in commercial tablets and rabbit plasma with excellent sensitivity and selectivity, which indicates its potential applications in clinical analysis and biologically related studies.

Authors:   Yang, Xiupei ; Liu, Mingxian ; Yin, Yanru ; Tang, Fenglin ; Xu, Hua ; Liao, Xiangjun
Journal:   Sensors
Volume:   18
edition:   4
Year:   2018
Pages:   964
DOI:   10.3390/s18040964
Publication date:   24-Mar-2018
Facts, background information, dossiers
  • plasma
  • photoluminescence
  • photoelectron spectroscopy
  • absorption
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