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Nitric oxide inhibitory constituents from Siegesbeckia pubescens

Publication date:

October 2018


Source:Bioorganic Chemistry, Volume 80

Author(s): Hari Jang, Jin Woo Lee, Jun Gu Kim, Hye Ryoung Hong, Thi Phoung Linh Le, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Two new sesquiterpenoids (1 and 2) and a new ent-pimarane type diterpenoid (3), together with eighteen known compounds (4–21), were isolated from the whole plants of Siegesbeckia pubescens. The structures of the new compounds were determined on the basis of 1D-, 2D NMR and HRESIMS data. All compounds were evaluated for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Of these, highly oxygenated germacrane type sesquiterpenoids (1–2 and 13–14) showed significant inhibitory effects with IC50 values ranging from 3.9 to 16.8 μM.
Graphical abstract




Authors:   Author(s): Hari Jang, Jin Woo Lee, Jun Gu Kim, Hye Ryoung Hong, Thi Phoung Linh Le, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang
Journal:   Bioorganic Chemistry
Volume:   80
Year:   2018
Pages:   81
DOI:   10.1016/j.bioorg.2018.05.022
Publication date:   11-Jun-2018
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