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Sophoflavanones A and B, two novel prenylated flavanones from the roots of Sophora flavescens

Publication date:

September 2018


Source:Bioorganic Chemistry, Volume 79

Author(s): Hui Zhu, Ya-nan Yang, Zi-ming Feng, Jian-shuang Jiang, Pei-cheng Zhang

In our ongoing investigation of the bioactive compounds from the extract of the roots of Sophora flavescens, two novel prenylated flavanones, named sophoflavanones A (1) and B (2), each with an unusual pyran ring were isolated. Their structures, as well as their absolute configurations, were elucidated based on spectroscopic data including a comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. Additionally, compounds 1 and 2 showed moderate antioxidant activities against Fe2+/cysteine-induced toxicity at a concentration of 0.1 µM (inhibition values of 71.65% and 72.49%, respectively, using vitamin C as a positive control (87.83%)).
Graphical abstract




Authors:   Author(s): Hui Zhu, Ya-nan Yang, Zi-ming Feng, Jian-shuang Jiang, Pei-cheng Zhang
Journal:   Bioorganic Chemistry
Volume:   79
Year:   2018
Pages:   122
DOI:   10.1016/j.bioorg.2018.04.019
Publication date:   11-Jun-2018
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