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In Situ Generation of Nitrile Oxides from Copper Carbene and tert-Butyl Nitrite: Synthesis of Fully Substituted Isoxazoles

Herein, we present a novel [3+2] cycloaddition reaction of -keto esters with nitrile oxides, which is generated in situ from copper carbene and tert-butyl nitrite. This three-component reaction provides a new methodology for the direct synthesis of fully substituted isoxazole derivatives, featuring the mild Synthetic methodology in OBC

Authors:   Xiaobing Wan; Rongxiang Chen; Abosede Adejoke Ogunlana; Shangwen Fang; Wenhao Long; Hong Mei Sun; Xiaoguang Bao
Journal:   Organic & Biomolecular Chemistry
DOI:   10.1039/C8OB01067F
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