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Molecules, Vol. 23, Pages 1386: 14-3-3: A Case Study in PPI Modulation

Molecules, Vol. 23, Pages 1386: 14-3-3: A Case Study in PPI Modulation

Molecules doi: 10.3390/molecules23061386

Authors: Alice Ballone Federica Centorrino Christian Ottmann

In recent years, targeting the complex network of protein–protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic conserved regulatory proteins which are of high interest as potential targets for pharmacological intervention in human diseases, such as cancer and neurodegenerative and metabolic disorders. This viewpoint is built on the “hub” nature of the 14-3-3 proteins, binding to several hundred identified partners, consequently implicating them in a multitude of different cellular mechanisms. In this review, we provide an overview of the structural and biological features of 14-3-3 and the modulation of 14-3-3 PPIs for discovering small molecular inhibitors and stabilizers of 14-3-3 PPIs.

Authors:   Ballone, Alice ; Centorrino, Federica ; Ottmann, Christian
Journal:   Molecules
Volume:   23
edition:   6
Year:   2018
Pages:   1386
DOI:   10.3390/molecules23061386
Publication date:   08-Jun-2018
Facts, background information, dossiers
  • small molecule inhibitors
  • interactions
  • drug discovery
  • diseases
  • cancer
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