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Mechanochemistry for “no solvent, no base” preparation of Hydantoin-based Active Pharmaceutical Ingredients: Nitrofurantoin and Dantrolene.

The eco-compatible, base- and waste-free, energy-efficient, low-environmental-impact, gram-scale, mechanochemical preparation of marketed drugs such as Nitrofurantoin (Furantin©), Dantrolene (Dantrium©) and their structurally related derivatives, is herein reported. Not a drop of organic solvent was used for

Authors:   Evelina Colacino; Andrea Porcheddu; Ivan Halasz; Clarence Charnay; Francesco Delogu; Ruben Guerra; Julien Fullenwarth
Journal:   Green Chemistry
DOI:   10.1039/C8GC01345D
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