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Protected 2'-deoxyribonucleoside triphosphate building blocks for photocaging of epigenetic 5-(hydroxymethyl)cytosine in DNA

2'-Deoxyribonucleoside triphosphates (dNTPs) containing 5-(hydroxymethyl)cytosine (5hmC) protected with photocleavable groups (2-nitrobenzyl or 6-nitropiperonyl) groups were prepared and studied as substrates for enzymatic synthesis of oligonucleotides and DNA containing photocaged epigenetic 5hmC base. DNA Chemical biology in OBC

Authors:   Sona Bohacova; Zuzana Vanikova; Lenka Slavetinska; Michal Hocek
Journal:   Organic & Biomolecular Chemistry
DOI:   10.1039/C8OB01106K
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