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Novel antitumor copper(II) complexes rationally designed to act through synergistic mechanisms of action, due to the presence of an NMDA receptor ligand and copper in the same chemical entity

In the present article the 1,4-dioxane derivative 1, a potent noncompetitive NMDA receptor antagonist, showed cytotoxic activity in MCF7 breast cancer cell line significantly higher than those of the functionally related compounds (S)-(+)-ketamine and MK-801. Encouraged by this result and considering that co

Authors:   Maria Beatrice Morelli; Consuelo Amantini; Giorgio Santoni; Maura Pellei; Carlo Santini; Cristina Cimarelli; Enrico Marcantoni; Marino Petrini; Fabio Del Bello; Gianfabio Giorgioni; Alessandro Piergentili; Wilma Quaglia
Journal:   New Journal of Chemistry
DOI:   10.1039/C8NJ01763H
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  • complexes
  • breast cancer
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