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Novel fluorinated platinum(II) complexes with pyridine-2-carboxylate ligand as potent radiosensitizer and antiviral agent

Publication date:

August 2018


Source:Inorganic Chemistry Communications, Volume 94

Author(s): Xiaoxiao Zhang, Fang Wang, Chao Zhang, Shuang Wu, Xuyang Zheng, Tuotuo Gong, Ruike Ding, Kai Chen, Dan Bai

Novel Pt(II) complexes, (TFPPy)PtPic and (TFPQ)PtPic, containing fluorinated phenylpyridine or phenylquinoline with pyridine-2-carboxylate as chelating ligands were synthesized according to rational design, their therapeutical activities examined. Remarkable radiosensitization SER values were observed even in radio-resistant cell line after treated with these complexes. Furthermore, the two complexes have shown antiviral activity against DNA virus HSV-1. Comply with live cell imaging results, molecular docking have revealed the complexes forms stable hydrogen bond and hydrophobic interactions to the minor groove of target DNA double helix. These findings demonstrate the non-classical structure complexes are promising for further evaluation as a new type of prodrug radiochemotherapy and antiviral treatment.
Graphical abstract




Authors:   Author(s): Xiaoxiao Zhang, Fang Wang, Chao Zhang, Shuang Wu, Xuyang Zheng, Tuotuo Gong, Ruike Ding, Kai Chen, Dan Bai
Journal:   Inorganic Chemistry Communications
Year:   2018
Publication date:   24-Jun-2018
Facts, background information, dossiers
  • complexes
  • pyridine
  • radiosensitizer
  • DNA double helix
  • bai
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