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Molecules, Vol. 23, Pages 1501: Chemical Profiling and Screening of the Marker Components in the Fruit of Cassia fistula by HPLC and UHPLC/LTQ-Orbitrap MSn with Chemometrics

Molecules, Vol. 23, Pages 1501: Chemical Profiling and Screening of the Marker Components in the Fruit of Cassia fistula by HPLC and UHPLC/LTQ-Orbitrap MSn with Chemometrics

Molecules doi: 10.3390/molecules23071501

Authors: Jiawei Tan Mengcheng Zheng Susu Duan Yanling Zeng Ziwei Zhang Qingyu Cui Jiamei Zhang Tingting Hong Jie Bai Shouying Du

Cassia fistula L. which is known as “Golden Shower”, is used as an ornamental plant due to its flowers, and fruit parts of this plant have a high medicinal value. There are few reports providing a comprehensive overview of the chemical composition of its fruit or explaining the differences between samples from different sources because of the complexity of its chemical components. The purpose of the present study was to establish a fingerprint evaluation system based on Similarity Analysis (SA), Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA) for the composition identification and quality control of this herb. Twelve samples from Xinjiang and Sichuan provinces in China and India were analyzed by HPLC, and there were fifteen common peaks in the twelve batches. Molecular weight and formula information can be derived from thirty-one peaks by UHPLC/LTQ-Orbitrap MSn, molecular structure information of twenty components was obtained, of which ten compounds were identified by comparison with standard materials. Samples of twelve batches were divided according to their similarity into four groups, which were basically consistent with three different C.fistula fruit-producing areas. Five compounds were finally considered to be chemical markers to determine the quality of this herb. A fingerprints method combined with chemometrics was established to differentiate the origin of the fruit of C. fistula which has the advantages of effectivity and convenience, laying the foundation for the quality evaluation of this herb from different sources.

Authors:   Tan, Jiawei ; Zheng, Mengcheng ; Duan, Susu ; Zeng, Yanling ; Zhang, Ziwei ; Cui, Qingyu ; Zhang, Jiamei ; Hong, Tingting ; Bai, Jie ; Du, Shouying
Journal:   Molecules
Volume:   23
edition:   7
Year:   2018
Pages:   1501
DOI:   10.3390/molecules23071501
Publication date:   21-Jun-2018
Facts, background information, dossiers
  • chemometrics
  • chemical composition
  • bai
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