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Synthesis of Hydrophobic Insulin-based Peptides Using a Helping-Hand Strategy

The introduction of solid-phase peptide synthesis in the 1960’s improved the chemical synthesis of both the A- and B-chains of insulin and insulin analogs. However, the subsequent elaboration of the synthetic peptides to generate active hormones continues to be difficult and complex due in part to the hydrop

Authors:   Maria Disotuar; Mark E Petersen; Jason M Nogueira; Michael S Kay; Danny Hung-chieh Chou
Journal:   Organic & Biomolecular Chemistry
DOI:   10.1039/C8OB01212A
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