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Fatty acid chemical mediator provides insights into the pathology and treatment of Parkinson’s disease [Neuroscience]

Parkinson’s disease (PD) ranks as the second-most prevalent neurodegenerative disorder that afflicts the aging population (1). Hallmark neuropathological features of PD consist of dopaminergic cell loss in the substantia nigra, striatal dopamine deficiency, and formation of intracellular inclusions, called Lewy bodies, marked by α-synuclein aggregates (2). Although the primary brain deficiency of PD involves nigrostriatal dopaminergic depletion, various cell types undergo degeneration in the brain, as well as in the periphery during disease onset and progression (3). The clinical symptoms of PD have been routinely defined as cardinal motor abnormalities, which include bradykinesia, tremors, muscle rigidity, and freezing of gait (1). However, PD is also associated with many nonmotor symptoms, such as cognitive deficits, that contribute to overall morbidity of the disease (1, 4). In addition to α-synuclein accumulation, several mechanisms postulated to mediate dopaminergic depletion comprise mitochondrial dysfunction, aberrant oxidative stress, calcium imbalance, impaired axonal transport, and neuroinflammation (1). The advent of disease biomarkers may facilitate early diagnosis and treatment initiation for PD. Unfortunately, despite these scientific advances in our knowledge of the disease pathology, there is no cure for PD, only relief from its symptoms. While dopaminergic cells are selectively destroyed in PD patients, what triggers this brain cell death remains poorly understood, thereby relegating treatment intervention to the … [↵][1]1Email: cborlong{at} [1]: #xref-corresp-1-1

Authors:   Cesar V. Borlongan
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   25
Year:   2018
Pages:   6322
DOI:   10.1073/pnas.1807276115
Publication date:   19-Jun-2018
Facts, background information, dossiers
  • pathology
  • brain
  • USF
  • tremors
  • oxidative stress
  • neuroscience
  • neuroinflammation
  • mitochondrial dysfunction
  • Lewy bodies
  • disorder
  • cells
  • cell death
More about Proceedings of the National Academy of Sciences
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