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Molecules, Vol. 23, Pages 1579: A Pharmacometabolomic Approach to Predict Response to Metformin in Early-Phase Type 2 Diabetes Mellitus Patients

Molecules, Vol. 23, Pages 1579: A Pharmacometabolomic Approach to Predict Response to Metformin in Early-Phase Type 2 Diabetes Mellitus Patients

Molecules doi: 10.3390/molecules23071579

Authors: Jeong-Eun Park Gui-Hwa Jeong In-Kyu Lee Young-Ran Yoon Kwang-Hyeon Liu Namyi Gu Kwang-Hee Shin

Metformin is a first-line medication for type 2 diabetes mellitus (T2DM). Based on its universal use, the consideration of inter-individual variability and development of predictive biomarkers are clinically significant. We aimed to identify endogenous markers of metformin responses using a pharmacometabolomic approach. Twenty-nine patients with early-phase T2DM were enrolled and orally administered metformin daily for 6 months. A total of 22 subjects were included in the final analysis. Patients were defined as responders or non-responders based on changes in their glycated haemoglobin A1c (HbA1c) from baseline, over 3 months. Urine metabolites at baseline, as well as at the 3 and 6 month follow-ups after the start of treatment were analysed using gas chromatography-mass spectrometry and evaluated with multivariate analyses. Metabolites distinguishable between the two response groups were obtained at baseline, as well as at the 3 and 6 month follow-ups, and significantly different metabolites were listed as markers of metformin response. Among the identified metabolites, citric acid, myoinositol, and hippuric acid levels showed particularly significant differences between the non-responder and responder groups. We thus identified different metabolite profiles in the two groups of T2DM patients after metformin administration, using pharmacometabolomics. These results might facilitate a better understanding and prediction of metformin response and its variability in individual patients.

Authors:   Park, Jeong-Eun ; Jeong, Gui-Hwa ; Lee, In-Kyu ; Yoon, Young-Ran ; Liu, Kwang-Hyeon ; Gu, Namyi ; Shin, Kwang-Hee
Journal:   Molecules
Volume:   23
edition:   7
Year:   2018
Pages:   1579
DOI:   10.3390/molecules23071579
Publication date:   29-Jun-2018
Facts, background information, dossiers
  • metformin
  • metabolites
  • type 2 diabetes
  • molecules
  • Total
  • medication
More about Molecular Diversity Preservation International
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