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Energy landscape of polymorphic amyloid generation of [small beta]2-microglobulin revealed by calorimetry

Understanding of amyloid aggregation in terms of thermodynamics and kinetics is still limited. We herein examined the mechanism of β2-microglobulin amyloidogenesis using our unique method of isothermal titration calorimetry-based thermodynamic and kinetic measurement, and revealed the energy landscape of pol Amyloid Aggregation

Authors:   Misaki Kinoshita; Yuxi Lin; Itoh Dai; Masaki Okumura; Natalia Markova; John E Ladbury; Fabio Sterpone; Young-Ho Lee
Journal:   Chemical Communication
DOI:   10.1039/C8CC02718H
Facts, background information, dossiers
  • aggregation
  • thermodynamics
  • kinetics
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