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Molecules, Vol. 23, Pages 1577: New Bisabosquals from Stachybotrys sp. PH30583 Elicited on Solid Media

Molecules, Vol. 23, Pages 1577: New Bisabosquals from Stachybotrys sp. PH30583 Elicited on Solid Media

Molecules doi: 10.3390/molecules23071577

Authors: Bao-Hui Ruan Shu-Quan Li Xue-Qiong Yang Ya-Bin Yang Ya-Mei Wu Li-Jiao Shi Hai-Yue Yin Hao Zhou Zhong-Tao Ding

Stachybotrys sp. PH30583 cultured in liquid medium only led to one structure type of novel isochroman dimers. Using the one strain-many compounds strategy, the reinvestigation of the metabolites from Stachybotrys sp. PH30583 cultured in rice solid medium led to the isolation of four triprenyl phenols, including two new bisabosquals and two known phenylspirodrimanes. Nitrobisabosquals A and B (1 and 2) are the first case of pyrrolidone-bisabosquals reported in literature. Totally different compounds were isolated using rice solid medium, compared with those isolated using liquid medium, so that rice solid medium presents a key factor in the production of triprenyl phenols. Compound 1 exhibited cytotoxicity against tumor cells, A-549, HL-60, MCF-7 SMMC-7721, and SW480, as well as weak anticoagulant activity with activated partial thromboplastin time (APTT) of 32.1 ± 0.17 s (p < 0.05 vs. Con.) at a concentration of 5 mM. Triprenyl phenol metabolites could be used as chemotaxonomic markers for Stachybotrys.

Authors:   Ruan, Bao-Hui ; Li, Shu-Quan ; Yang, Xue-Qiong ; Yang, Ya-Bin ; Wu, Ya-Mei ; Shi, Li-Jiao ; Yin, Hai-Yue ; Zhou, Hao ; Ding, Zhong-Tao
Journal:   Molecules
Volume:   23
edition:   7
Year:   2018
Pages:   1577
DOI:   10.3390/molecules23071577
Publication date:   29-Jun-2018
Facts, background information, dossiers
  • metabolites
  • concentration
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