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Molecules, Vol. 23, Pages 1559: A One-Pot Biginelli Synthesis and Characterization of Novel Dihydropyrimidinone Derivatives Containing Piperazine/Morpholine Moiety

Molecules, Vol. 23, Pages 1559: A One-Pot Biginelli Synthesis and Characterization of Novel Dihydropyrimidinone Derivatives Containing Piperazine/Morpholine Moiety

Molecules doi: 10.3390/molecules23071559

Authors: Mashooq Ahmad Bhat Mohamed A. Al-Omar Hazem A. Ghabbour Ahmed M. Naglah

Enaminones, 4-methyl-1-[4-(piperazin/morpholin-1-yl) phenyl] pent-2-en-1-one (IIa–b) were synthesized by refluxing 1-[4-(piperazin/morpholin-1-yl) phenyl] ethan-1-one (Ia–b) with dimethylformamide dimethylacetal (DMF–DMA) without any solvent. The three dimensional structure of enaminone (IIb) containing morpholine moiety was confirmed by single crystal X-ray crystallography. Finally, the dihydropyrimidinone derivatives (1–20) were obtained by reacting enaminones (IIa–b) with urea and different substituted benzaldehydes in the presence of glacial acetic acid. Dihydropyrimidinone derivatives containing piperazine/morpholine moiety were synthesized in a good yield by means of simple and efficient method.

Authors:   Bhat, Mashooq Ahmad; Al-Omar, Mohamed A.; Ghabbour, Hazem A.; Naglah, Ahmed M.
Journal:   Molecules
Volume:   23
edition:   7
Year:   2018
Pages:   1559
DOI:   10.3390/molecules23071559
Publication date:   27-Jun-2018
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  • Dimethylformamide
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