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Microfluidic chambers using fluid walls for cell biology [Cell Biology]

Despite improvements in our ability to manipulate ever-smaller volumes, most workflows in cell biology still use volumes of many microliters. We describe a method for creating microfluidic arrangements containing submicroliter volumes. It exploits interfacial forces dominant at the microscale to confine liquids with fluid (not solid) walls. We demonstrate many basic manipulations required for cell culture and some widely used downstream workflows. The method eliminates many problems associated with the fabrication of conventional microfluidic devices, thereby providing a simple on-demand approach for fabrication of microfluidic devices using materials familiar to biologists.

Authors:   Cristian Soitu; Alexander Feuerborn; Ann Na Tan; Henry Walker; Pat A. Walsh; Alfonso A. Castrejón-Pita; Peter R. Cook; Edmond J. Walsh
Journal:   Proceedings of the National Academy of Sciences current issue
Volume:   115
edition:   26
Year:   2018
Pages:   E5926
DOI:   10.1073/pnas.1805449115
Publication date:   26-Jun-2018
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  • biologists
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