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The discovery of a freezing-induced peptide ligation during the total chemical synthesis of human interferon-ε

A counterintuitive freezing-induced peptide ligation was discovered in the total synthesis of human interferon-ε (hIFN-ε) which blocks HIV infection through unique mechanisms. The successful synthesis of hIFN-ε (187 amino acids) in this research laid the foundation for related anti-AIDS drug development. Mor Chemical biology in OBC

Authors:   Yin-He Yang; Bin Di; Da-Song Yang
Journal:   Organic & Biomolecular Chemistry
DOI:   10.1039/C8OB01365A
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  • Research
  • interferon
  • HIV
  • amino acids
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