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IJERPH, Vol. 15, Pages 1352: Exposure to Environmental Contaminants and Lung Function in Adolescents—Is There a Link?

IJERPH, Vol. 15, Pages 1352: Exposure to Environmental Contaminants and Lung Function in Adolescents—Is There a Link?

International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15071352

Authors: Marike M. Leijs Janna G. Koppe Kees Olie Pim de Voogt Wim M. C. van Aalderen Gavin W. ten Tusscher

Dioxins (polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDF)), polychlorinated biphenyls (PCBs), and brominated flame retardants (BDEs) are well known toxic environmental contaminants. Their possible role in the incidence of respiratory disease is not yet well understood. Previous studies showed a negative effect on lung function in relation to prenatal and lactational dioxin exposure in pre-pubertal children. Effects of BDE exposure on the lung function have not previously been evaluated. As part of a longitudinal cohort study, the effects of perinatal dioxin (PCDD/F) exposure and serum PCDD/F, dl-PCB, and BDE levels on lung function in adolescents were assessed using spirometry, a body box, and diffusion measurements. Thirty-three children (born between 1986 and 1991) consented to the current follow-up study. Prenatal, lactational, and current dioxin, PCB, and BDE concentrations were determined using GC-MS. No relationship was seen between prenatal and lactational dioxin exposure, nor with current PCB body burden, and lung function. Indications of increasing airway obstruction were seen in relation to increasing current BDE exposure. This is a novel finding and certainly warrants further research.

Authors:   Leijs, Marike M.; Koppe, Janna G.; Olie, Kees ; de Voogt, Pim ; van Aalderen, Wim M. C.; ten Tusscher, Gavin W.
Journal:   International Journal of Environmental Research and Public Health
Volume:   15
edition:   7
Year:   2018
Pages:   1352
DOI:   10.3390/ijerph15071352
Publication date:   27-Jun-2018
Facts, background information, dossiers
  • BDE
  • Research
  • lung function
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