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IJMS, Vol. 19, Pages 1930: Recent Progress in Gene Therapy for Ovarian Cancer

IJMS, Vol. 19, Pages 1930: Recent Progress in Gene Therapy for Ovarian Cancer

International Journal of Molecular Sciences doi: 10.3390/ijms19071930

Authors: Ángela Áyen Yaiza Jiménez Martínez Juan A. Marchal Houria Boulaiz

Ovarian cancer is the most lethal gynecological malignancy in developed countries. This is due to the lack of specific symptoms that hinder early diagnosis and to the high relapse rate after treatment with radical surgery and chemotherapy. Hence, novel therapeutic modalities to improve clinical outcomes in ovarian malignancy are needed. Progress in gene therapy has allowed the development of several strategies against ovarian cancer. Most are focused on the design of improved vectors to enhance gene delivery on the one hand, and, on the other hand, on the development of new therapeutic tools based on the restoration or destruction of a deregulated gene, the use of suicide genes, genetic immunopotentiation, the inhibition of tumour angiogenesis, the alteration of pharmacological resistance, and oncolytic virotherapy. In the present manuscript, we review the recent advances made in gene therapy for ovarian cancer, highlighting the latest clinical trials experience, the current challenges and future perspectives.

Authors:   Áyen, Ángela ; Jiménez Martínez, Yaiza ; Marchal, Juan A.; Boulaiz, Houria
Journal:   International Journal of Molecular Sciences
Volume:   19
edition:   7
Year:   2018
Pages:   1930
DOI:   10.3390/ijms19071930
Publication date:   30-Jun-2018
Facts, background information, dossiers
  • ovarian cancer
  • gene therapy
  • vectors
  • surgery
  • suicide
  • gene delivery
  • diagnosis
  • clinical trials
  • chemotherapy
  • angiogenesis
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