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The proportion of Met80-sulfoxide dictates peroxidase activity of human cytochrome c

The peroxidase activity of cytochrome c is proposed to contribute to apoptosis by peroxidation of cardiolipin in the mitochondrial inner membrane. However, cytochrome c heme is hexa-coordinate with a methionine (Met80) on the distal side, stopping it from acting as an efficient peroxidase. The first naturally occur

Authors:   Rinky D. Parakra; Torsten Kleffmann; Guy N. L. Jameson; Elizabeth C. Ledgerwood
Journal:   Dalton Transactions
DOI:   10.1039/C8DT02185F
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  • apoptosis
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