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A[small beta] under stress: the effects of acidosis, Cu2+-binding, and oxidation on amyloid [small beta]-peptide dimers

In light of the high affinity of Cu2+ for Alzheimer's Aβ1–42 and its ability to subsequently catalyze the formation of radicals, we examine the effects of Cu2+ binding, Aβ oxidation, and an acidic environment on the conformational dynamics of the smallest Aβ1–42 oligomer, the Aβ1–42 dimer. Transition networks calcu Amyloid Aggregation

Authors:   Qinghua Liao; Michael C. Owen; Sofia Bali; Bogdan Barz; Birgit Strodel
Journal:   Chemical Communication
DOI:   10.1039/C8CC02263A
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  • aggregation
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