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Molbank, Vol. 2018, Article 1002: 2-[2-Methyl-5-phenyl-1-(3,4,5-trimethoxyphenyl)-1H-pyrrol-3-yl]-2-oxo-N-(pyridin-4-yl) acetamide

Molbank, Vol. 2018, Article 1002: 2-[2-Methyl-5-phenyl-1-(3,4,5-trimethoxyphenyl)-1H-pyrrol-3-yl]-2-oxo-N-(pyridin-4-yl) acetamide

Molbank doi: 10.3390/M1002

Authors: Ebrahim Saeedian Moghadam Mohsen Amini

We synthesized 2-[2-methyl-5-phenyl-1-(3,4,5-trimethoxyphenyl)-1H-pyrrol-3-yl]-2-oxo-N-(pyridin-4-yl) acetamide 4 as a novel compound derived from the indibulin and combretastatin scaffolds, which are known anti-mitotic agents, using a multistep reaction. We tested its cytotoxic activity against three breast cancer cell lines, namely, MCF-7, T47-D, and MDA-MB 231 as well as normal cell line NIH-3T3, by 3-(4,5-dimethylthiazoyl-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The biological activity results showed good cytotoxicity on cancerous cell lines (IC50 value 27.7–39.2 µM) and low toxicity on normal cell line (NIH-3T3, IC50 value > 100 µM).

Authors:   Saeedian Moghadam, Ebrahim ; Amini, Mohsen
Journal:   Molbank
Volume:   2018
edition:   3
Year:   2018
Pages:   1002
DOI:   10.3390/M1002
Publication date:   28-Jun-2018
Facts, background information, dossiers
  • cytotoxicity
  • cell lines
  • breast cancer
More about Molecular Diversity Preservation International
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