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IJMS, Vol. 19, Pages 1874: Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol

IJMS, Vol. 19, Pages 1874: Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol

International Journal of Molecular Sciences doi: 10.3390/ijms19071874

Authors: Qi-Yuan Yang Qian-Qian Cao Qi-Pin Qin Cai-Xing Deng Hong Liang Zhen-Feng Chen

Two transition metal complexes with 2-((2-(pyridin-2-yl)hydrazono)methyl)quinolin-8-ol (L), [Cu(L)Cl2]2 (1) and [Ni(L)Cl2]·CH2Cl2 (2), were synthesized and fully characterized. Complex 1 exhibited high in vitro antitumor activity against SK-OV-3, MGC80-3 and HeLa cells with IC50 values of 3.69 ± 0.16, 2.60 ± 0.17, and 3.62 ± 0.12 μM, respectively. In addition, complex 1 caused cell arrest in the S phase, which led to the down-regulation of Cdc25 A, Cyclin B, Cyclin A, and CDK2, and the up-regulation of p27, p21, and p53 proteins in MGC80-3 cells. Complex 1 induced MGC80-3 cell apoptosis via a mitochondrial dysfunction pathway, as shown by the significantly decreased level of bcl-2 protein and the loss of Δψ, as well as increased levels of reactive oxygen species (ROS), intracellular Ca2+, cytochrome C, apaf-1, caspase-3, and caspase-9 proteins in MGC80-3 cells.

Authors:   Yang, Qi-Yuan ; Cao, Qian-Qian ; Qin, Qi-Pin ; Deng, Cai-Xing ; Liang, Hong ; Chen, Zhen-Feng
Journal:   International Journal of Molecular Sciences
Volume:   19
edition:   7
Year:   2018
Pages:   1874
DOI:   10.3390/ijms19071874
Publication date:   26-Jun-2018
Facts, background information, dossiers
  • proteins
  • transition metal complexes
  • reactive oxygen species
  • nickel
  • mitochondrial dysfunction
  • HeLa cells
  • cytochrome c
  • crystal structures
  • copper
  • complexes
  • cells
  • CAI
More about Molecular Diversity Preservation International
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