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Molecules, Vol. 23, Pages 1563: Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation

Molecules, Vol. 23, Pages 1563: Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation

Molecules doi: 10.3390/molecules23071563

Authors: Zhi-Peng Li Hong-Bing Liu Quan-Wei Zhang Li-Feng Li Wan-Rong Bao Dik-Lung Ma Chung-Hang Leung Zhao-Xiang Bian Ai-Ping Lu Quan-Bin Han

Polysaccharides, which exert immunoregulatory effects, are becoming more and more popular as food supplements; however, certain components of ordinary foods could be reducing the polysaccharides beneficial effects. Quercetin, a flavonoid found in common fruits and vegetables, is one such component. This study investigated the effects of quercetin on Astragalus polysaccharide RAP induced-macrophage activation. The results show quercetin decreases the NO production and iNOS gene expression in RAW264.7 cells, and it inhibits the production of cytokines in RAW264.7 cells and peritoneal macrophages. Western blot analysis results suggest that quercetin inhibits the phosphorylation of Akt/mTORC1, MAPKs, and TBK1, but has no effect on NF-κB in RAP-induced RAW264.7 cells. Taken together, the results show that quercetin partly inhibits macrophage activation by the Astragalus polysaccharide RAP. This study demonstrates that quercetin-containing foods may interfere with the immune-enhancing effects of Astragalus polysaccharide RAP to a certain extent.

Authors:   Li, Zhi-Peng ; Liu, Hong-Bing ; Zhang, Quan-Wei ; Li, Li-Feng ; Bao, Wan-Rong ; Ma, Dik-Lung ; Leung, Chung-Hang ; Bian, Zhao-Xiang ; Lu, Ai-Ping ; Han, Quan-Bin
Journal:   Molecules
Volume:   23
edition:   7
Year:   2018
Pages:   1563
DOI:   10.3390/molecules23071563
Publication date:   28-Jun-2018
Facts, background information, dossiers
  • quercetin
  • polysaccharides
  • molecules
  • vegetables
  • production
  • phosphorylation
  • macrophages
  • interference
  • gene expression
  • fruits
  • food supplements
  • cytokines
More about Molecular Diversity Preservation International
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