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Total Synthesis of the Proposed Structure of Talarolide A

The proposed structure of talarolide A, a cycloheptapeptide featuring a hydroxamate moiety within the peptide backbone, was successfully synthesized. An initial attempt to synthesize a linear peptide precursor containing a C-terminal N-benzyloxy glycine residue was problematic due to an an unreported on-resi Synthetic methodology in OBC Total synthesis in OBC

Authors:   Margaret A Brimble; Shengping Zhang; Luis Manuel M De Leon Rodriguez; Ivanhoe K. H. Leung; Paul Harrs; Renjie Huang
Journal:   Organic & Biomolecular Chemistry
DOI:   10.1039/C8OB01230J
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