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IJMS, Vol. 19, Pages 1921: Dietary Leucine Supplement Ameliorates Hepatic Steatosis and Diabetic Nephropathy in db/db Mice

IJMS, Vol. 19, Pages 1921: Dietary Leucine Supplement Ameliorates Hepatic Steatosis and Diabetic Nephropathy in db/db Mice

International Journal of Molecular Sciences doi: 10.3390/ijms19071921

Authors: Kuan-Hsing Chen Yi-Ling Chen Hsiang-Yu Tang Cheng-Chieh Hung Tzung-Hai Yen Mei-Ling Cheng Ming-Shi Shiao Jan-Kan Chen

Dietary leucine supplementation has been explored for the therapeutic intervention of obesity and obesity-induced metabolic dysfunctions. In this study, we aim to examine the effects of dietary leucine supplementation in db/db mice. Mice were treated with or without leucine (1.5% w/v) in drinking water for 12 weeks. The leucine supplement was found to reduce insulin resistance and hepatic steatosis in db/db mice. Using Nuclear Magnetic Resonance (NMR)-based lipidomics, we found that the reduction of hepatic triglyceride synthesis was correlated with attenuated development of fatty liver. In addition, diabetic nephropathy (DN) was also ameliorated by leucine. Using liquid chromatography–time-of-flight mass spectrometry (LC-TOF MS)-based urine metabolomics analysis, we found that the disturbance of the tricarboxylic acid (TCA) cycle was reversed by leucine. The beneficial effects of leucine were probably due to AMP-activated protein kinase (AMPK) activation in the liver and kidneys of db/db mice. Thus, dietary leucine supplementation may potentially be a nutritional intervention to attenuate hepatic steatosis and early DN in type II diabetes.

Authors:   Chen, Kuan-Hsing ; Chen, Yi-Ling ; Tang, Hsiang-Yu ; Hung, Cheng-Chieh ; Yen, Tzung-Hai ; Cheng, Mei-Ling ; Shiao, Ming-Shi ; Chen, Jan-Kan
Journal:   International Journal of Molecular Sciences
Volume:   19
edition:   7
Year:   2018
Pages:   1921
DOI:   10.3390/ijms19071921
Publication date:   30-Jun-2018
Facts, background information, dossiers
  • leucine
  • obesity
  • liver
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