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Versatile coordination of acetazolamide to ruthenium(II) p-cymene complexes and preliminary cytotoxicity studies

The carbonic anhydrase inhibitor acetazolamide (AcmH2) reacted with [(η6-p-cymene)RuCl(μ-Cl)]2 to afford [(η6-p-cymene)RuCl2(κN-AcmH2)], 1A, in near-quantitative yield. In methanol, 1A exists in equilibrium with 1B, being probably a coordination isomer, as established by VT 1H-EXSY NMR spectroscopy. DFT calculation

Authors:   Lorenzo Biancalana; Lucinda K. Batchelor; Gianluca Ciancaleoni; Stefano Zacchini; Guido Pampaloni; Paul J. Dyson; Fabio Marchetti
Journal:   Dalton Transactions
DOI:   10.1039/C8DT01555D
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