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Kinetic barriers to [small alpha]-synuclein protofilament formation and conversion into mature fibrils

Oligomeric and protofibrillar aggregates that are populated along the pathway of amyloid fibril formation appear generally to be more toxic than the mature fibrillar state. In particular, α-synuclein, the protein associated with Parkinson's disease, forms kinetically trapped protofibrils in the presence of lipid ve

Authors:   James W. P. Brown; Georg Meisl; Tuomas P. J. Knowles; Alexander K. Buell; Christopher M. Dobson; Céline Galvagnion
Journal:   Chemical Communication
DOI:   10.1039/C8CC03002B
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