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Molbank, Vol. 2009, Pages M590: Synthesis of 3-(4-Chloro-2-methoxy-7H-pyrrolo[2,3-d]-pyrimidin-7-yl)propanoic acid – An N(9)-Functionalized 7-Deazapurine

Regioselective N-alkylation of 4-chloro-2-methoxy-7H-pyrrolo[2,3- d]pyrimidine (6) with ethyl 3-bromopropionate under liquid-liquid phase-transfer reactionconditions gave the ester 7a. Its saponification yielded the acid 7b. The logP values of a series of N(9)-functionalized purines and purine isosteres were calculated.

Authors:   Rosemeyer, Helmut
Journal:   Molbank
Volume:   2009
edition:   1
Year:   2009
Pages:   M590
DOI:   10.3390/M590
Publication date:   06-Feb-2009
Facts, background information, dossiers
  • N-Alkylation
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