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Novel 5[prime or minute]-deoxy nucleosyl amino acid scaffolds for the synthesis of muraymycin analogues

Naturally occurring nucleoside antibiotics such as muraymycins represent promising lead structures for the development of novel antibacterial agents. A concise synthesis of 5[prime or minute]-deoxy muraymycin derivatives has been developed. The key step was the highly stereoselective asymmetric hydrogenation of suitable didehydro amino acid precursors, providing unique nucleosyl amino acid structures.

Authors:   Anatol P. Spork; Christian Ducho
Journal:   Organic & Biomolecular Chemistry
Volume:   8
edition:   10
Year:   2010
Pages:   2323
DOI:   10.1039/C003092A
Publication date:   12-Apr-2010
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