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Synthesis of New Pyrano[2,3-d]Pyrazoles and Furochromones Derivatives Utilizing Amino Acids Derivatives

. Hydrolysis of oxazolone derivatives (2b) yielded a-khellinoyl(amino)-cinnamic acid (3) as a good precursor to react with ethyl esters of glycine, l-methionine, and glycylglycine affording 4, 5, and 4,5 respectively with minor product 7. Hydrolysis of oxazolone derivatives (2b) afforded a,b-dehydroamino acid derivatives (DDAA) (8). Interaction of oxazolone derivatives (2a,b) with active methylene compounds as ethyl acetoacetate, malononitrile, ethylcyanoacetate, and cyanoacetamide afforded 9-16 respectively.

  • Content Type Journal Article
  • Pages 121-128
  • DOI 10.1007/s007830050067
  • Authors
    • N.M. Fawzy, National Research Centre, Dokki, Cairo, Egypt. E-mail: mzaki@nrc.sci.eg
    • A.M. Shalaby, National Research Centre, Dokki, Cairo, Egypt. E-mail: mzaki@nrc.sci.eg
    • M.E.A. Zaki, National Research Centre, Dokki, Cairo, Egypt. E-mail: mzaki@nrc.sci.eg
    • Journal Molecules Online
    • Online ISSN 1433-1373
    • Journal Volume Volume 2
    • Journal Issue Volume 2, Numbers 10-11

Authors:   N.M. Fawzy, A.M. Shalaby, M.E.A. Zaki
Journal:   Molecules Online
Year:   2004
DOI:   10.1007/s007830050067
Publication date:   19-Feb-2004
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