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IJERPH, Vol. 8, Pages 3579-3590: Cancer Incidence of 2,4-D Production Workers

Despite showing no evidence of carcinogenicity in laboratory animals, the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) has been associated with non-Hodgkin lymphoma (NHL) in some human epidemiology studies, albeit inconsistently. We matched an existing cohort of 2,4-D manufacturing employees with cancer registries in three US states resulting in 244 cancers compared to 276 expected cases. The Standardized Incidence Ratio (SIR) for the 14 NHL cases was 1.36 (95% Confidence Interval (CI) 0.74–2.29). Risk estimates were higher in the upper cumulative exposure and duration subgroups, yet not statistically significant. There were no clear patterns of NHL risk with period of hire and histology subtypes. Statistically significant results were observed for prostate cancer (SIR = 0.74, 95% CI 0.57–0.94), and “other respiratory” cancers (SIR = 3.79, 95% CI 1.22–8.84; 4 of 5 cases were mesotheliomas). Overall, we observed fewer cancer cases than expected, and a non statistically significant increase in the number of NHL cases.

Authors:   Carol Burns; Kenneth Bodner; Gerard Swaen; James Collins; Kathy Beard; Marcia Lee
Journal:   International Journal of Environmental Research and Public Health
Volume:   8
edition:   9
Year:   2011
Pages:   3579
Publication date:   02-Sep-2011
Facts, background information, dossiers
  • cancer
  • prostate cancer
  • non-Hodgkin lymphoma
  • laboratory animals
  • histology
  • acids
More about Molecular Diversity Preservation International
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