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Inflammatory markers in preeclamptic patients

Abstract Background: Preeclampsia is characterized by hypertension and proteinuria that begins in the second half of pregnancy. Endothelial dysfunction and trophoblastic hypoperfusion seen in preeclampsia suggested to be part of an increased maternal inflammatory response to pregnancy. In this study, we aimed to evaluate some inflammatory markers in pre-eclamptic and normotensive pregnants. Methods: The study included 36 cases with mild preeclamp-sia, 36 cases with severe preeclampsia and 33 cases of normotensive pregnant. High sensitive C-reactive protein (hsCRP) and serum amyloid A (SAA) were measured by enzyme-linked immunosorbent assays, serum procalcitonin was measured by enzyme-linked fluorescent immunassay. Mean arterial pressure (MAP) was used as an indicator of the severity of the disease. Results: In severe preeclampsia group hsCRP, serum amyloid A and procalcitonin levels were significantly higher than mild preeclamptic and normotensive groups. SAA and hsCRP levels were higher in mild preeclamp...

Authors:   Murat Can; Eray Sancar; Muge Harma; Berrak Guven; Gorkem Mungan; Serefden Acikgoz
Journal:   Clinical Chemistry
Year:   2011
DOI:   10.1515/CCLM.2011.232
Publication date:   13-Sep-2011
Facts, background information, dossiers
  • preeclampsia
  • pressure
  • hypertension
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